adas-core/adas-core.Test/Customizations/H12O/UCIN/CalculatedObservationsTest.cs

using adas_core.Application.Customizations.H12O.UCIN;
using adas_core.Application.Services.Interfaces;
using adas_core.Domain.Enums;
using adas_core.Domain.Models;
using adas_core.Domain.Models.AppSettings;
using Microsoft.Extensions.DependencyInjection;
using Microsoft.Extensions.Logging;
using Microsoft.Extensions.Options;
using MongoDB.Bson;
using Moq;
using Options = Microsoft.Extensions.Options.Options;

namespace adas_core.Test.Customizations.H12O.UCIN;

/// <summary>
/// Represents a test fixture that contains unit tests for calculated observations, executing with an order priority of 2 relative to other test fixtures.
/// </summary>
/// <remarks>
/// This fixture is annotated with <see cref="TestFixtureAttribute"/> to mark it as a container of NUnit test methods, and with <see cref="OrderAttribute"/> to control its execution sequence within the test suite.
/// </remarks>
/// <!-- aidoc:v1 sig=d5b9e22 -->
[TestFixture]
[Order(2)]
public class CalculatedObservationsTest
{
    /// <summary>
    /// Initializes the test fixture for <see cref="CalculatedObservations"/> by creating mocked instances of
    /// <see cref="IObservationService"/>, <see cref="IConfigObservationService"/>, <see cref="IMedicineService"/>,
    /// <see cref="ITreatmentService"/>, and <see cref="ILogger{CalculatedObservations}"/>, configuring
    /// <see cref="IOptions{TOptions}"/> settings for medication bolus, transcutaneous, regional brain saturation,
    /// electroencephalogram, respiratory, high-frequency ventilation, invasive ventilation, non-invasive
    /// ventilation, one-lung isolation, and ECMO codes, and registering all dependencies in a
    /// <see cref="ServiceCollection"/> so that a fully wired <see cref="CalculatedObservations"/> instance
    /// is produced for each test.
    /// </summary>
    /// <!-- aidoc:v1 sig=dee8bf2 body=3c4f27b -->
    [SetUp]
    public void Setup()
    {
        _observationServiceMock = new Mock<IObservationService>();

        _configOservationServiceMock = new Mock<IConfigObservationService>();

        _medicineServiceMock = new Mock<IMedicineService>();

        _treatmentServiceMock = new Mock<ITreatmentService>();

        _logger = new Mock<ILogger<CalculatedObservations>>();

        _optionsApiSettings = Options.Create(_apiSettings);

        _optionsApiSettings.Value.MedicationBolus = ["18851000140100", "21011000140105"];
        _optionsApiSettings.Value.IntravenousLinesCode = ["10546003"];
        _optionsApiSettings.Value.Transcutaneous = ["151756", "151760"];
        _optionsApiSettings.Value.RegionalBrainSaturation = ["194908", "194909"];
        _optionsApiSettings.Value.Electroencephalogram = ["42803009"];
        _optionsApiSettings.Value.Respiratory = ["361110005", "84481000140102"];
        _optionsApiSettings.Value.HighFrequencyVentilation = ["PC-HFO"];
        _optionsApiSettings.Value.InvasiveVentilation =
        [
            "A/C  (S.I.P.P.V. )", "A/C  (S.I.P.P.V.) + V.G.", "PRVC", "PC-SIMV", "SIMV-PRVC", "PC-AC", "SIMV",
            "SIMV-PC", "S.I.M.V.", "PC-CMV", "SIPPV", "PC"
        ];
        _optionsApiSettings.Value.NonInvasiveVentilation = ["DUOPAP", "NCPAP"];
        _optionsApiSettings.Value.Oni = ["84481000140102", "416362002"];
        _optionsApiSettings.Value.Ecmo = ["705923009"];
        var serviceCollection = new ServiceCollection();
        //serviceCollection.AddSingleton(_observationServiceMock.Object);
        serviceCollection.AddSingleton(new Lazy<IObservationService>(() => _observationServiceMock.Object));

        serviceCollection.AddSingleton(
            new Lazy<IConfigObservationService>(() => _configOservationServiceMock.Object));
        serviceCollection.AddSingleton(_medicineServiceMock.Object);
        serviceCollection.AddSingleton(new Lazy<ITreatmentService>(() => _treatmentServiceMock.Object));
        serviceCollection.AddSingleton(_optionsApiSettings);
        serviceCollection.AddSingleton(_logger.Object);

        var serviceProvider = serviceCollection.BuildServiceProvider();

        _calculatedObservations = new CalculatedObservations(serviceProvider);
    }

    private CalculatedObservations _calculatedObservations;
    private Mock<IMedicineService> _medicineServiceMock;
    private Mock<IObservationService> _observationServiceMock;
    private Mock<IConfigObservationService> _configOservationServiceMock;
    private Mock<ITreatmentService> _treatmentServiceMock;
    private Mock<ILogger<CalculatedObservations>> _logger;

    private readonly ApiSettings _apiSettings = new()
    {
        ConfigObservation = new ConfigObservationSettings
        {
            IgnoreUnknownObservation = false
        }
    };

    private IOptions<ApiSettings> _optionsApiSettings;

    /// <summary>
    /// Verifies that processing a new <see cref="PatientTreatment"/> that contains a medicine—matched by code to a known <see cref="Medicine"/> with an assigned <see cref="MedicineEnum.Types"/>—for the first time for a patient (no prior observations and no active treatments) results in a <see cref="PatientObservation"/> named <c>Medication</c> with value <c>1</c> associated to the treatment's <see cref="PatientTreatment.PatientId"/>.
    /// </summary>
    /// <!-- aidoc:v1 sig=e86b69e body=2015ef3 -->
    [Test]
    public async Task Calculate_First_Medicine_Observation_With_Type_Should_Return_1()
    {
        //Entra un tratamiento por primera vez con una medicina, se crea una observación medication con valor 1
        var patientId = ObjectId.GenerateNewId();

        var treatment =
            new PatientTreatment
            {
                Id = ObjectId.GenerateNewId(),
                PatientId = patientId,
                OrderControl = OrderControlType.Nw,
                PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                RequestedGiveCodes = [new Code { Identifier = "12345" }],
                OrderStatus = "A",
                OrderTime = DateTime.Now,
                Notes = [],
                Routes = []
            };

        var medicine =
            new Medicine
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Type = [MedicineEnum.Types.MuscleRelaxant.ToString()],
                Name = "cisataracurio"
            };

        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "12345" }))
            .ReturnsAsync([medicine]);
        _observationServiceMock.Setup(o => o.InsertObservation(It.IsAny<PatientObservation>(), true, true));
        _observationServiceMock.Setup(o => o.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);
        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(new List<Medicine>().AsEnumerable());


        await _calculatedObservations.Map(treatment);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Medication" && (int)arg.Value == 1 && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that mapping a new <see cref="PatientTreatment"/> containing a medicine, when no prior
    /// observations or active treatments exist for the patient, results in the insertion of a
    /// <see cref="PatientObservation"/> named "Medication" with value <c>0</c> for the patient.
    /// </summary>
    /// <!-- aidoc:v1 sig=9a4b425 body=8e4c1db -->
    [Test]
    public async Task Calculate_First_Medicine_Observation_With_Out_Type_Should_Return_1()
    {
        //Entra un tratamiento por primera vez con una medicina, se crea una observación medication con valor 1
        var patientId = ObjectId.GenerateNewId();

        var treatment =
            new PatientTreatment
            {
                Id = ObjectId.GenerateNewId(),
                PatientId = patientId,
                OrderControl = OrderControlType.Nw,
                PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                RequestedGiveCodes = [new Code { Identifier = "12345" }],
                OrderStatus = "A",
                OrderTime = DateTime.Now,
                Notes = [],
                Routes = []
            };

        var medicine =
            new Medicine
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Name = "cisataracurio"
            };

        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "12345" }))
            .ReturnsAsync([medicine]);
        _observationServiceMock.Setup(o => o.InsertObservation(It.IsAny<PatientObservation>(), true, true));
        _observationServiceMock.Setup(o => o.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);
        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(new List<Medicine>().AsEnumerable());


        await _calculatedObservations.Map(treatment);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Medication" && (int)arg.Value == 0 && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that when a new <see cref="PatientTreatment"/> with an <c>OrderControl</c> of <see cref="OrderControlType.Nw"/> is mapped for the first time and contains a medicine code, a <see cref="PatientObservation"/> with name <c>Medication</c> and value <c>1</c> is inserted for the patient.
    /// </summary>
    /// <!-- aidoc:v1 sig=58845f5 body=90a5eab -->
    [Test]
    public async Task Calculate__Medicine_Observation_New_Type_Should_Sum_1()
    {
        //Entra un tratamiento por primera vez con una medicina, se crea una observación medication con valor 1
        var patientId = ObjectId.GenerateNewId();

        var treatment =
            new PatientTreatment
            {
                Id = ObjectId.GenerateNewId(),
                PatientId = patientId,
                OrderControl = OrderControlType.Nw,
                PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                RequestedGiveCodes = [new Code { Identifier = "12345" }],
                OrderStatus = "A",
                OrderTime = DateTime.Now,
                Notes = [],
                Routes = []
            };

        var medicine =
            new Medicine
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Name = "cisataracurio",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            };

        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "12345" }))
            .ReturnsAsync([medicine]);
        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(new List<Medicine>().AsEnumerable());
        _observationServiceMock.Setup(o => o.InsertObservation(It.IsAny<PatientObservation>(), true, true));


        _observationServiceMock.Setup(o => o.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(treatment);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Medication" && (int)arg.Value == 1 && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that when a new <see cref="PatientTreatment"/> is mapped and a prior <see cref="PatientObservation"/> of name "Medication" with value 0 already exists for the patient, the calculated observations service inserts a new observation with value 1 (the sum of the existing value 0 plus the new contribution).
    /// </summary>
    /// <!-- aidoc:v1 sig=cb5c407 body=b26efc0 -->
    [Test]
    public async Task Calculate__Medicine_Observation_Type_Already_Exists_Should_Sum_0()
    {
        //Entra un tratamiento por primera vez con una medicina, se crea una observación medication con valor 1
        var patientId = ObjectId.GenerateNewId();

        var treatment =
            new PatientTreatment
            {
                Id = ObjectId.GenerateNewId(),
                PatientId = patientId,
                OrderControl = OrderControlType.Nw,
                PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                RequestedGiveCodes = [new Code { Identifier = "12345" }],
                OrderStatus = "A",
                OrderTime = DateTime.Now,
                Notes = [],
                Routes = []
            };

        var medicine =
            new Medicine
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Name = "cisataracurio",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            };

        var activeMedicines = new List<Medicine>
        {
            new()
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Name = "Biotin",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            }
        };

        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "12345" }))
            .ReturnsAsync([medicine]);
        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(activeMedicines.AsEnumerable());
        _observationServiceMock.Setup(o => o.InsertObservation(It.IsAny<PatientObservation>(), true, true));
        _observationServiceMock.Setup(o => o.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([
                new PatientObservation
                {
                    PatientId = patientId,
                    Value = 0,
                    Name = "Medication"
                }
            ]);


        await _calculatedObservations.Map(treatment);


        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Medication"
            && (int)arg.Value == 1
            && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that when a medicine observation of type <see cref="OrderControlType.Dc"/> already exists for the patient,
    /// <see cref="CalculatedObservations.Map(PatientTreatment)"/> subtracts the existing value and inserts a new observation with a resulting value of 0.
    /// </summary>
    /// <returns>A <see cref="Task"/> representing the asynchronous unit test execution.</returns>
    /// <!-- aidoc:v1 sig=91b1fbb body=81816e9 -->
    [Test]
    public async Task Calculate__Medicine_Observation_DC_Type_Already_Exists_Should_Subtract_0()
    {
        var patientId = ObjectId.GenerateNewId();

        var treatment =
            new PatientTreatment
            {
                Id = ObjectId.GenerateNewId(),
                PatientId = patientId,
                OrderControl = OrderControlType.Dc,
                PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                RequestedGiveCodes = [new Code { Identifier = "12345" }],
                OrderStatus = "A",
                OrderTime = DateTime.Now,
                Notes = [],
                Routes = []
            };

        var medicine =
            new Medicine
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Name = "cisataracurio",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            };

        var activeMedicines = new List<Medicine>
        {
            new()
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Name = "cisataracurio",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            }
        };

        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "12345" }))
            .ReturnsAsync([medicine]);
        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(activeMedicines.AsEnumerable());
        _observationServiceMock.Setup(o => o.InsertObservation(It.IsAny<PatientObservation>(), true, true));
        _observationServiceMock.Setup(o => o.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([
                new PatientObservation(patientId, 1, "Medication")
            ]);


        await _calculatedObservations.Map(treatment);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "ERMedication" && (int)arg.Value == 0 && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that when a <see cref="OrderControlType.Dc"/> treatment is processed and the patient has two active medicines, a <c>Medication</c> observation is inserted with the last observation value decremented by one (2 - 1 = 1).
    /// </summary>
    /// <!-- aidoc:v1 sig=a244df0 body=151d371 -->
    [Test]
    public async Task Calculate__Medicine_Observation_DC_OF_TYPE_WITH_TWO_MEDICINES_Should_Subtract_0()
    {
        //Entra un tratamiento por primera vez con una medicina, se crea una observación medication con valor 1
        var patientId = ObjectId.GenerateNewId();

        var treatment =
            new PatientTreatment
            {
                Id = ObjectId.GenerateNewId(),
                PatientId = patientId,
                OrderControl = OrderControlType.Dc,
                PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                RequestedGiveCodes = [new Code { Identifier = "12345" }],
                OrderStatus = "A",
                OrderTime = DateTime.Now,
                Notes = [],
                Routes = []
            };

        var medicine =
            new Medicine
            {
                Codes = ["12345"],
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Name = "cisataracurio",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            };

        var activeMedicines = new List<Medicine>
        {
            new()
            {
                Codes = ["12345"],
                Name = "cisataracurio",
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            },

            new()
            {
                Codes = ["12345"],
                Name = "Lipoic acid",
                Group = [MedicineEnum.Group.DoubleSignature.ToString()],
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            }
        };

        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "12345" }))
            .ReturnsAsync([medicine]);
        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(activeMedicines.AsEnumerable());
        _observationServiceMock.Setup(o => o.InsertObservation(It.IsAny<PatientObservation>(), true, false));

        _observationServiceMock.Setup(o => o.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([
                new PatientObservation
                {
                    PatientId = patientId,
                    Value = 2,
                    Name = "Medication"
                }
            ]);

        //_observationServiceMock.Setup(o => o.InsertObservation(It.Is<PatientObservation>(arg => 
        //    (arg.Name == "ERMedication" && (int)arg.Value == 1) 
        //    && arg.PatientId == patientId
        //), true, true));


        await _calculatedObservations.Map(treatment);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Medication"
            && (int)arg.Value == 1
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that mapping a new <see cref="PatientTreatment"/> containing a medicine without a defined type results in the insertion of a <see cref="PatientObservation"/> named "Medication" with a value of 1 for the associated patient.
    /// </summary>
    /// <!-- aidoc:v1 sig=9e218b6 body=fd802ff -->
    [Test]
    public async Task Calculate_Medicine_Observation_New_Medicine_Without_Type_Should_Insert_Medication_1_point()
    {
        //Entra un tratamiento por primera vez con una medicina, se crea una observación medication con valor 1
        var patientId = ObjectId.GenerateNewId();

        var treatment =
            new PatientTreatment
            {
                Id = ObjectId.GenerateNewId(),
                PatientId = patientId,
                OrderControl = OrderControlType.Nw,
                PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
                RequestedGiveCodes = [new Code { Identifier = "12345" }],
                OrderStatus = "A",
                OrderTime = DateTime.Now,
                Notes = [],
                Routes = []
            };

        var medicine =
            new Medicine
            {
                Codes = ["12345"],
                Name = "Betaine"
            };

        var activeMedicines = new List<Medicine>
        {
            new()
            {
                Codes = ["12345"],
                Name = "cisataracurio",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            },

            new()
            {
                Codes = ["12345"],
                Name = "Lipoic acid",
                Type = [MedicineEnum.Types.AdrenalineNoradrenaline.ToString()]
            }
        };


        var expectedMedication = new PatientObservation
        {
            PatientId = patientId,
            Value = 0,
            Name = "Medication"
        };


        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "12345" }))
            .ReturnsAsync([medicine]);
        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(activeMedicines.AsEnumerable());
        _observationServiceMock.Setup(o => o.InsertObservation(It.IsAny<PatientObservation>(), true, true));
        _observationServiceMock.Setup(o => o.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([expectedMedication]);


        await _calculatedObservations.Map(treatment);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Medication"
            && (int)arg.Value == 1
            && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that <see cref="PatientObservation"/>.<see cref="PatientObservation.Map"/> inserts a new
    /// <see cref="PatientIntravenousLinesValue"/> observation with a score of <c>5</c> when processing the first
    /// intravenous arterial observation for a patient, given that no previous observations exist.
    /// </summary>
    /// <!-- aidoc:v1 sig=a3cd1e1 body=93b85d0 -->
    [Test]
    public async Task Calculate_First_Intravenous_Arterial_Observation_Should_Return_5()
    {
        var patientId = ObjectId.GenerateNewId();

        var obs = new PatientObservation
        {
            PatientId = patientId,
            Value = new PatientIntravenousLinesValue
            {
                Action = "Insert",
                Duration = "7",
                InsertTime = DateTime.Now,
                Location = "Rodilla",
                Type = "Catéter arterial"
            },
            Name = "IntravenousLinesObs"
        };


        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        _observationServiceMock.Setup(t => t.FindLastIntravenousLinesObservationByLocation(patientId))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(obs, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "IntravenousLines"
            && (int)arg.Value == 5
            && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that when a previous <see cref="PatientObservation"/> for the same patient and location has already been removed, the intravenous calculation performed by <see cref="CalculatedObservations.Map"/> produces a result of 0.
    /// </summary>
    /// <!-- aidoc:v1 sig=ca5324a body=aae89b4 -->
    [Test]
    public async Task Calculate_Intravenous_Obs_Already_Exist_Removed_Should_Return_0()
    {
        var patientId = ObjectId.GenerateNewId();
        var now = DateTime.Now;

        var obs = new PatientObservation
        {
            PatientId = patientId,
            Value = new PatientIntravenousLinesValue
            {
                Action = "Insert",
                Duration = "7",
                InsertTime = now,
                Location = "Rodilla",
                Type = "Catéter arterial",
                RemoveTime = DateTime.Now.AddDays(1)
            },
            Name = "IntravenousLinesObs"
        };

        _observationServiceMock.Setup(t => t.FindLastIntravenousLinesObservationByLocation(patientId))
            .ReturnsAsync([]);

        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([
                new PatientObservation
                {
                    PatientId = patientId,
                    Value = new PatientIntravenousLinesValue
                    {
                        Action = "Insert",
                        Duration = "7",
                        InsertTime = now,
                        Type = "Catéter arterial",
                        Location = "Rodilla"
                    },
                    Name = "IntravenousLinesObs"
                }
            ]);

        await _calculatedObservations.Map(obs, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "IntravenousLines"
            && (int)arg.Value == 0
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that mapping a <see cref="PatientObservation"/> with an <see cref="PatientIntravenousLinesValue"/> whose type and location match the last stored observation for the same patient does not trigger an insertion of a calculated "IntravenousLines" observation.
    /// </summary>
    /// <!-- aidoc:v1 sig=076ddee body=f4d6ebd -->
    [Test]
    public async Task Calculate_Intravenous_two_observations_of_same_type_and_same_location_should_return_null()
    {
        var patientId = ObjectId.GenerateNewId();
        var now = DateTime.Now;

        var obs = new PatientObservation
        {
            PatientId = patientId,
            Name = "IntravenousLinesObs",
            Value = new PatientIntravenousLinesValue
            {
                Action = "Insertado",
                Duration = "7",
                InsertTime = now,
                Location = "Rodilla",
                Type = "Catéter arterial"
            }
        };

        _observationServiceMock.Setup(t => t.FindLastIntravenousLinesObservationByLocation(patientId))
            .ReturnsAsync([
                new PatientObservation
                {
                    PatientId = patientId,
                    Value = new PatientIntravenousLinesValue
                    {
                        Action = "Insertado",
                        Duration = "7",
                        InsertTime = now,
                        Type = "Catéter arterial",
                        Location = "Rodilla"
                    },
                    Name = "IntravenousLinesObs"
                }
            ]);


        await _calculatedObservations.Map(obs, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "IntravenousLines"
            && (int)arg.Value == 5
            && arg.PatientId == patientId
        ), true, true), Times.Never);
    }

    /// <summary>
    /// Verifies that when a new PatientObservation of type "IntravenousLinesObs" is processed alongside a previous observation of the same type for the same patient, the calculator produces a derived PatientObservation named "IntravenousLines" with a value of 10.
    /// </summary>
    /// <!-- aidoc:v1 sig=fd6a90d body=bae7c5e -->
    [Test]
    public async Task Calculate_Intravenous_two_observations_of_same_type_should_return_10()
    {
        var patientId = ObjectId.GenerateNewId();
        var now = DateTime.Now;

        var obs = new PatientObservation
        {
            PatientId = patientId,
            Name = "IntravenousLinesObs",
            Value = new PatientIntravenousLinesValue
            {
                Action = "Insertado",
                Duration = "7",
                InsertTime = now,
                Location = "Rodilla",
                Type = "Catéter arterial"
            }
        };

        _observationServiceMock.Setup(t => t.FindLastIntravenousLinesObservationByLocation(patientId))
            .ReturnsAsync([
                new PatientObservation
                {
                    PatientId = patientId,
                    Name = "IntravenousLinesObs",
                    Value = new PatientIntravenousLinesValue
                    {
                        Action = "Insertado",
                        Duration = "7",
                        InsertTime = now,
                        Type = "Catéter arterial",
                        Location = "Codo"
                    }
                }
            ]);

        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(obs, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "IntravenousLines"
            && (int)arg.Value == 10
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that the <see cref="Map"/> method limits the calculated sum of <see cref="PatientIntravenousLinesValue"/> observations to a maximum value of ten when the total exceeds that threshold.
    /// </summary>
    /// <!-- aidoc:v1 sig=8681a17 body=b0efb6d -->
    [Test]
    public async Task Calculate_Intravenous_sum_more_than_10_should_limit_to_ten()
    {
        var patientId = ObjectId.GenerateNewId();
        var now = DateTime.Now;

        var obs = new PatientObservation
        {
            PatientId = patientId,
            Value = new PatientIntravenousLinesValue
            {
                Action = "Insertado",
                Duration = "7",
                InsertTime = now,
                Location = "Rodilla Izd.",
                Type = "Catéter arterial"
            },
            Name = "IntravenousLinesObs"
        };

        var patientObservations = new List<PatientObservation?>
        {
            new()
            {
                PatientId = patientId,
                Name = "IntravenousLinesObs",
                Value = new PatientIntravenousLinesValue
                {
                    Action = "Insertado",
                    Duration = "7",
                    InsertTime = now,
                    Type = "Catéter arterial",
                    Location = "Rodilla Der."
                }
            },
            new()
            {
                PatientId = patientId,
                Name = "IntravenousLinesObs",
                Value = new PatientIntravenousLinesValue
                {
                    Action = "Insertado",
                    Duration = "7",
                    InsertTime = now,
                    Type = "Catéter PICC",
                    Location = "Brazo"
                }
            }
        };

        _observationServiceMock.Setup(t => t.FindLastIntravenousLinesObservationByLocation(patientId))
            .ReturnsAsync(patientObservations);
        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(obs, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "IntravenousLines"
            && (int)arg.Value == 10
            && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that mapping a new <see cref="PatientObservation"/> with a "Catéter línea media" type, when two prior intravenous lines exist (one "Catéter EPICUTÁNEO PERIFÉRICO" and one "Catéter Venoso PERIFÉRICO"), inserts an <see cref="PatientObservation"/> named "IntravenousLines" with a summed value of 5 for the given <paramref name="patientId"/>.
    /// </summary>
    /// <!-- aidoc:v1 sig=1e74e0a body=1cc02b8 -->
    [Test]
    public async Task Calculate_Intravenous_sum_one_middle_line_and_two_Peripheral_should_return_5()
    {
        var patientId = ObjectId.GenerateNewId();
        var now = DateTime.Now;

        var obs = new PatientObservation
        {
            PatientId = patientId,
            Value = new PatientIntravenousLinesValue
            {
                Action = "Insertado",
                Duration = "7",
                InsertTime = now,
                Location = "Rodilla Izd.",
                Type = "Catéter línea media"
            },
            Name = "IntravenousLinesObs"
        };

        _observationServiceMock.Setup(t => t.FindLastIntravenousLinesObservationByLocation(patientId))
            .ReturnsAsync([
                new PatientObservation
                {
                    PatientId = patientId,
                    Name = "IntravenousLinesObs",
                    Value = new PatientIntravenousLinesValue
                    {
                        Action = "Insertado",
                        Duration = "7",
                        InsertTime = now,
                        Type = "Catéter EPICUTÁNEO PERIFÉRICO",
                        Location = "Rodilla Der."
                    }
                },

                new PatientObservation
                {
                    PatientId = patientId,
                    Name = "IntravenousLinesObs",
                    Value = new PatientIntravenousLinesValue
                    {
                        Action = "Insertado",
                        Duration = "7",
                        InsertTime = now,
                        Type = "Catéter Venoso PERIFÉRICO",
                        Location = "Brazo"
                    }
                }
            ]);

        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(obs, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "IntravenousLines"
            && (int)arg.Value == 5
            && arg.PatientId == patientId
        ), true, false));
    }


    /// <summary>
    /// Verifies that <see cref="_calculatedObservations"/>.<see cref="_calculatedObservations.Map"/> produces a monitor observation with value 3 for a treatment containing the EEG code <c>42803009</c>, based on the most recent transcutaneous and regional brain saturation observations retrieved for the patient.
    /// </summary>
    /// <!-- aidoc:v1 sig=a0a8af2 body=b1ce181 -->
    [Test]
    public async Task Calculate_Monitor_Transcuatenous_Regional_Brain_Saturation_and_enter_EEG_should_return_3()
    {
        var patientId = ObjectId.GenerateNewId();

        var treatment = new PatientTreatment
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            OrderControl = OrderControlType.Nw,
            PlacerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
            FillerOrder = new Entity { EntityIdentifier = "100", NamespaceId = "CareVue" },
            RequestedGiveCodes = [new Code { Identifier = "42803009" }],
            OrderStatus = "NW",
            OrderTime = DateTime.Now,
            Notes = [],
            Routes = []
        };


        _treatmentServiceMock.Setup(t => t.GetActiveTreatmentsByPatient(patientId))
            .ReturnsAsync(new List<PatientTreatment>().AsEnumerable());
        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(new List<string> { "42803009" }))
            .ReturnsAsync([]);

        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([
                new PatientObservation
                {
                    PatientId = patientId,
                    Code = "151756",
                    Name = "Transcutaneous",
                    Time = DateTime.Now
                },


                new PatientObservation
                {
                    PatientId = patientId,
                    Code = "151760",
                    Name = "Transcutaneous",
                    Time = DateTime.Now
                },


                new PatientObservation
                {
                    PatientId = patientId,
                    Code = "194908",
                    Name = "RegionalBrainSaturation",
                    Time = DateTime.Now
                },

                new PatientObservation
                {
                    PatientId = patientId,
                    Code = "194909",
                    Name = "RegionalBrainSaturation",
                    Time = DateTime.Now
                }
            ]);

        await _calculatedObservations.Map(treatment);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Monitor"
            && (int)arg.Value == 3
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that mapping a ventilation <see cref="PatientObservation"/> with value <c>OXIDO NITRICO 800 PPM MOL</c> for a patient with no prior observations produces a derived <see cref="PatientObservation"/> named "Respiratory" with an integer value of 10.
    /// </summary>
    /// <!-- aidoc:v1 sig=c24a7f7 body=316af0f -->
    [Test]
    public async Task Calculate_Respiratory_INO_should_return_10()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "OXIDO NITRICO 800 PPM MOL",
            Code = "84481000140102",
            Name = "Tipo de ventilación",
            CodingSystem = "SNM"
        };


        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(observation, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Respiratory"
            && (int)arg.Value == 10
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that <see cref="RespiratoryCalculations.Map"/> calculates a respiratory value of 5 when the patient observation
    /// represents a "V.A.F.O." (ventilación de alta frecuencia oscilatoria) entry coded as <c>361110005</c> in the SNM coding system,
    /// using an empty list returned by <see cref="IPatientObservationService.FindLastObservations"/>.
    /// </summary>
    /// <returns>A <see cref="Task"/> that completes when the assertions have been executed.</returns>
    /// <!-- aidoc:v1 sig=ff64ea1 body=e0741e9 -->
    [Test]
    public async Task Calculate_Respiratory_VAFO_should_return_5()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "V.A.F.O.",
            Code = "361110005",
            Name = "Tipo de ventilación",
            CodingSystem = "SNM"
        };


        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(observation, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Respiratory"
            && (int)arg.Value == 5
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that mapping a <see cref="PatientObservation"/> with value "V.M.C." (ventilation type, SNOMED code "361110005") produces a calculated respiratory observation with value <c>3</c> for the same <see cref="PatientObservation.PatientId"/>, when no previous observations are returned by the observation service.
    /// </summary>
    /// <!-- aidoc:v1 sig=b50bb78 body=fbe450e -->
    [Test]
    public async Task Calculate_Respiratory_VMC_should_return_3()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "V.M.C.",
            Code = "361110005",
            Name = "Tipo de ventilación",
            CodingSystem = "SNM"
        };


        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(observation, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Respiratory"
            && (int)arg.Value == 3
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that mapping a <see cref="PatientObservation"/> with the ventilation type <c>V.N.I. Ciclada</c> (Non-Invasive Mechanical Ventilation) results in the insertion of a calculated respiratory observation with an integer value of <c>2</c> for the same patient.
    /// </summary>
    /// <!-- aidoc:v1 sig=8bbe6fe body=f6304b9 -->
    [Test]
    public async Task Calculate_Respiratory_VMNI_should_return_2()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "V.N.I. Ciclada",
            Code = "361110005",
            Name = "Tipo de ventilación",
            CodingSystem = "SNM"
        };


        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(observation, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Respiratory"
            && (int)arg.Value == 2
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that when a <see cref="PatientObservation"/> with name "Tipo de ventilación" and value "Bajo Flujo" is mapped, a calculated respiratory observation is inserted with value 1 for the associated patient.
    /// </summary>
    /// <!-- aidoc:v1 sig=dc95390 body=7ee3ef7 -->
    [Test]
    public async Task Calculate_Respiratory_Nassal_Canulas_Bajo_Flujo_should_return_2()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "Bajo Flujo",
            Code = "361110005",
            Name = "Tipo de ventilación",
            CodingSystem = "SNM"
        };

        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);


        await _calculatedObservations.Map(observation, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Respiratory"
            && (int)arg.Value == 1
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.Map"/> returns a respiratory value of 1 when the patient observation indicates an "Alto Flujo" (high flow nasal cannula) ventilation type, identified by <see cref="PatientObservation.Code"/> "361110005" in the SNM coding system.
    /// </summary>
    /// <!-- aidoc:v1 sig=513d3e9 body=b065156 -->
    [Test]
    public async Task Calculate_Respiratory_Nassal_Canulas_Alto_Flujo_should_return_1()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "Alto Flujo",
            Code = "361110005",
            Name = "Tipo de ventilación",
            CodingSystem = "SNM"
        };


        _observationServiceMock.Setup(t => t.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.Map(observation, false);

        _observationServiceMock.Verify(o => o.InsertObservation(It.Is<PatientObservation>(arg =>
            arg.Name == "Respiratory"
            && (int)arg.Value == 1
            && arg.PatientId == patientId
        ), true, false));
    }

    /// <summary>
    /// Verifies that mapping a <see cref="PatientObservation"/> with the name "Resp_Mode" and the value "PC-AC"
    /// produces a calculated observation for "Resp_Type" using the "ADAS" coding system with the
    /// <see cref="RespirationType.Invasive"/> value.
    /// </summary>
    /// <!-- aidoc:v1 sig=b5d9b6c body=e8d6f79 -->
    [Test]
    public async Task Calculate_Ventilation_Mode_Returns_INVASIVE()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "PC-AC",
            Name = "Resp_Mode"
        };

        await _calculatedObservations.Map(observation, false);
        _observationServiceMock.Verify(o => o.InsertIfChanged("Resp_Type", It.Is<PatientObservation>(arg =>
            arg.Name == "Resp_Type" &&
            arg.CodingSystem == "ADAS" &&
            arg.Value.ToString() == RespirationType.Invasive.ToString()
        ), true, true));
    }

    /// <summary>
    /// Verifies that mapping a <see cref="PatientObservation"/> with the name <c>Resp_Mode</c> and value <c>DUOPAP</c> triggers an insert of a new observation named <c>Resp_Type</c> using the <see cref="RespirationType.NonInvasive"/> value.
    /// </summary>
    /// <!-- aidoc:v1 sig=f5e26c4 body=47ff0a9 -->
    [Test]
    public async Task Calculate_Ventilation_Mode_Returns_NON_INVASIVE()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "DUOPAP",
            Name = "Resp_Mode"
        };

        await _calculatedObservations.Map(observation, false);
        _observationServiceMock.Verify(o => o.InsertIfChanged("Resp_Type", It.Is<PatientObservation>(arg =>
            arg.Name == "Resp_Type" &&
            arg.CodingSystem == "ADAS" &&
            arg.Value.ToString() == RespirationType.NonInvasive.ToString()
        ), true, true));
    }

    /// <summary>
    /// Verifies that mapping a <see cref="PatientObservation"/> with the <c>Resp_Mode</c> name and the <c>PC-HFO</c> value produces a calculated observation named <c>Resp_Type</c> using the <c>ADAS</c> coding system whose value resolves to <see cref="RespirationType.HighFrequencyVentilation"/>.
    /// </summary>
    /// <!-- aidoc:v1 sig=0b62048 body=f640d1b -->
    [Test]
    public async Task Calculate_Ventilation_Mode_Returns_HIGH_FREQUENCY()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "PC-HFO",
            Name = "Resp_Mode"
        };

        await _calculatedObservations.Map(observation, false);
        _observationServiceMock.Verify(o => o.InsertIfChanged("Resp_Type", It.Is<PatientObservation>(arg =>
            arg.Name == "Resp_Type" &&
            arg.CodingSystem == "ADAS" &&
            arg.Value.ToString() == RespirationType.HighFrequencyVentilation.ToString()
        ), true, true));
    }

    /// <summary>
    /// Verifies that when a <see cref="PatientObservation"/> with <see cref="PatientObservation.Name"/> "Resp_Mode" and <see cref="PatientObservation.Value"/> "VENTAPNEA" is mapped, the calculated observation for "Resp_Type" is produced with <see cref="RespirationType.None"/> using the "ADAS" coding system.
    /// </summary>
    /// <returns>A <see cref="Task"/> representing the asynchronous test execution.</returns>
    /// <!-- aidoc:v1 sig=d1932f8 body=7b268e3 -->
    [Test]
    public async Task Calculate_Ventilation_Mode_Returns_NONE()
    {
        var patientId = ObjectId.GenerateNewId();

        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Value = "VENTAPNEA",
            Name = "Resp_Mode"
        };

        await _calculatedObservations.Map(observation, false);
        _observationServiceMock.Verify(o => o.InsertIfChanged("Resp_Type", It.Is<PatientObservation>(arg =>
            arg.Name == "Resp_Type" &&
            arg.CodingSystem == "ADAS" &&
            arg.Value.ToString() == RespirationType.None.ToString()
        ), true, true));
    }

    /// <summary>
    /// Verifies that CalculateOxygenationIndex retrieves the latest AirPressure_Mean, FiO2, and PaO2
    /// <see cref="PatientObservation"/> values for the patient via FindLastObservations and inserts a new
    /// <see cref="PatientObservation"/> named "Oxygenation_Index" with the correctly computed value of 1250.
    /// </summary>
    /// <!-- aidoc:v1 sig=c1d2ff2 body=25f4ca1 -->
    [Test]
    public async Task CalculateOxygenationIndex_ShouldInsertCorrectObservation()
    {
        var patientId = ObjectId.GenerateNewId();
        var observation = new PatientObservation
        {
            PatientId = patientId,
            Name = "FiO2",
            Value = 50
        };

        var observations = new List<PatientObservation>
        {
            new() { Name = "AirPressure_Mean", Value = 20, PatientId = patientId },
            new() { Name = "FiO2", Value = 50, PatientId = patientId },
            new() { Name = "PaO2", Value = 80, PatientId = patientId }
        };

        _observationServiceMock.Setup(s => s.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync(observations);

        await _calculatedObservations.CalculateOxygenationIndex(observation);


        _observationServiceMock.Verify(s => s.InsertObservation(
            It.Is<PatientObservation>(o =>
                o.Name == "Oxygenation_Index" && o.PatientId == patientId && (int)o.Value == 1250),
            It.IsAny<bool>(), It.IsAny<bool>()));
    }

    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.CalculateAsistResp(BasePatientObservation)"/> inserts a new
    /// <see cref="PatientObservation"/> with the name <c>Respiratory</c> for the patient when the most recent
    /// retrieved observation matches the expected respiratory mode (<c>Resp_Mode</c>), and returns the
    /// original <paramref name="observation"/>.
    /// </summary>
    /// <!-- aidoc:v1 sig=52c29ce body=d802db9 -->
    [Test]
    public async Task CalculateAsistResp_ShouldUpdateObservation_WhenConditionsMet()
    {
        var patientId = ObjectId.GenerateNewId();
        var observation = new PatientObservation
        {
            PatientId = patientId,
            Name = "ONi",
            Value = "valor",
            Time = DateTime.Now,
            Code = "codigo"
        };

        var lastAsistResp = new PatientObservation
        {
            PatientId = patientId,
            Name = "Resp_Mode",
            Value = "valor",
            Time = DateTime.Now.AddMinutes(-10)
        };

        _observationServiceMock.Setup(s => s.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([lastAsistResp]);

        var result = await _calculatedObservations.CalculateAsistResp(observation);

        _observationServiceMock.Verify(s => s.InsertObservation(
            It.Is<PatientObservation>(o => o.Name == "Respiratory" && o.PatientId == patientId),
            It.IsAny<bool>(), It.IsAny<bool>()));

        Assert.That(result, Is.EqualTo(observation));
    }

    // [TestCase("valorHFV", RespirationType.HIGH_FREQUENCY_VENTILATION)]
    // [TestCase("valorInvasive", RespirationType.INVASIVE)]
    // [TestCase("valorNonInvasive", RespirationType.NON_INVASIVE)]
    // [TestCase("valorNone", RespirationType.NONE)]
    /// <summary>
    /// Verifies that <see cref="CalculateVentilationMode"/> maps the supplied input value to the expected <see cref="RespirationType"/> and persists it as a <c>Resp_Type</c> observation via <see cref="PatientObservationService.InsertIfChanged"/>.
    /// Handles the localized input cases <c>valorHFV</c> (mapped to <c>PC-HFO</c>), <c>valorInvasive</c> (mapped to <c>PRVC</c>), and <c>valorNonInvasive</c> (mapped to <c>DUOPAP</c>); any other value falls back to <paramref name="expectedRespType"/>.
    /// </summary>
    /// <param name="value">The raw <c>Resp_Mode</c> input value from the observation; when it does not match a known ventilation label, it is replaced by <paramref name="expectedRespType"/>.</param>
    /// <param name="expectedRespType">The <see cref="RespirationType"/> expected to be inserted as <c>Resp_Type</c> after the calculation runs.</param>
    /// <!-- aidoc:v1 sig=f257d24 body=b077ba8 -->
    public async Task CalculateVentilationMode_ShouldInsertCorrectRespType(string value,
        RespirationType expectedRespType)
    {
        var patientId = ObjectId.GenerateNewId();
        var observation = new PatientObservation
        {
            PatientId = patientId,
            Name = "Resp_Mode",
            Time = DateTime.Now,
            Value = value switch
            {
                "valorHFV" => "PC-HFO",
                "valorInvasive" => "PRVC",
                "valorNonInvasive" => "DUOPAP",
                _ => expectedRespType
            }
        };
        await _calculatedObservations.CalculateVentilationMode(observation);

        _observationServiceMock.Verify(s => s.InsertIfChanged(
            "Resp_Type",
            It.Is<PatientObservation>(o =>
                o.PatientId == patientId && o.Name == "Resp_Type" && o.Value.ToString() == expectedRespType.ToString()),
            It.IsAny<bool>(), It.IsAny<bool>()));
    }


    // [TestCase("TAm", 10, 12, ObservationStatus.Ok)]
    // [TestCase("Age_Gestational", 1, 2, ObservationStatus.Alert)]
    // [TestCase("Age_Gestational", 1, 12, ObservationStatus.Ok)]
    // [TestCase("Age_Gestational_Fixed", 5, 10, ObservationStatus.Ok)]
    /// <summary>
    /// Verifies that the <c>CalculateTAmAlert</c> method updates the status of a <c>TAm</c> observation
    /// to the expected <see cref="StatusEnum.Type"/> when the observation name is "TAm", and inserts a new
    /// <c>TAm</c> observation when the name is "Age_Gestational" or "Age_Gestational_Fixed".
    /// </summary>
    /// <param name="observationName">The name of the observation under test, expected to be "TAm", "Age_Gestational", or "Age_Gestational_Fixed".</param>
    /// <param name="tamValue">The numeric TAm value assigned to the observation and related grouped observations.</param>
    /// <param name="gestationalAge">The numeric gestational age value used in the related grouped observations.</param>
    /// <param name="expectedType">The expected <see cref="StatusEnum.Type"/> used to assert the resulting observation status.</param>
    /// <!-- aidoc:v1 sig=8451823 body=20a4dd1 -->
    public async Task CalculateTAmAlert_ShouldUpdateStatusCorrectly(string observationName, int tamValue,
        int gestationalAge, StatusEnum.Type expectedType)
    {
        var patientId = ObjectId.GenerateNewId();
        var observation = new PatientObservation
        {
            PatientId = patientId,
            Name = observationName,
            Value = tamValue,
            Time = DateTime.Now,
            Status = expectedType
        };
        List<PatientObservation> groupedObservations = [];
        switch (observationName)
        {
            case "TAm":
                groupedObservations =
                [
                    new PatientObservation
                    {
                        Name = "Age_Gestational", Value = gestationalAge, PatientId = patientId,
                        Time = DateTime.Now.AddMinutes(-10), Status = expectedType
                    },
                    new PatientObservation
                    {
                        Name = "Age_Gestational_Fixed", Value = gestationalAge, PatientId = patientId,
                        Time = DateTime.Now.AddMinutes(-10), Status = expectedType
                    }
                ];
                break;
            case "Age_Gestational":
            case "Age_Gestational_Fixed":
                groupedObservations =
                [
                    new PatientObservation
                    {
                        Name = "Age_Gestational", Value = gestationalAge, PatientId = patientId,
                        Time = DateTime.Now.AddMinutes(-10), Status = expectedType
                    },
                    new PatientObservation
                    {
                        Name = "TAm", Value = tamValue, PatientId = patientId, Time = DateTime.Now.AddMinutes(-10),
                        Status = expectedType
                    }
                ];
                break;
        }

        _observationServiceMock.Setup(s => s.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync(groupedObservations);

        await _calculatedObservations.CalculateTAmAlert(observation);

        if (observation.Name == "TAm")
            Assert.That(observation.Status, Is.EqualTo(expectedType));
        else
            _observationServiceMock.Verify(s => s.InsertObservation(
                It.Is<PatientObservation>(o => o.PatientId == patientId && o.Name == "TAm"),
                It.IsAny<bool>(), It.IsAny<bool>()));
    }
    /// <summary>
    /// Verifies that the ParseWeight method correctly converts the units to "gr" and scales the value (multiplying by 1000) when given a valid <see cref="PatientObservation"/> with a numeric <see cref="PatientObservation.Value"/>.
    /// </summary>
    /// <!-- aidoc:v1 sig=dd3fee8 body=5df6de0 -->
    [Test]
    public async Task ParseWeight_WhenValidObservation_ShouldConvertUnitsAndValue()
    {
        var obs = new PatientObservation
        {
            Value = 1.23
        };

        var result = await _calculatedObservations.ParseWeight(obs) as PatientObservation;

        Assert.That(result, Is.Not.Null);

        Action assertions = () =>
        {
            Assert.That(result!.Units, Is.EqualTo("gr"));
            Assert.That(result.Value, Is.EqualTo(1230));
        };

        Assert.Multiple(assertions);
    }


    /// <summary>
    /// Verifies that ParseWeight handles non-numeric <see cref="PatientObservation.Value"/> gracefully by returning the original <see cref="PatientObservation"/> unchanged.
    /// </summary>
    /// <!-- aidoc:v1 sig=e9945f6 body=ed7a0ab -->
    [Test]
    public async Task ParseWeight_WhenValueIsNotNumeric_ShouldHandleGracefullyAndReturnOriginal()
    {
        var obs = new PatientObservation
        {
            Value = "string"
        };
        var result = await _calculatedObservations.ParseWeight(obs);
        Assert.That(result, Is.EqualTo(obs));
    }

    /// <summary>
    /// Verifies that the ParseWeight method returns the original <see cref="BasePatientObservation"/> unchanged when the observation cannot be converted to a <c>PatientObservation</c>, exercising the fallback behavior for invalid input types.
    /// </summary>
    /// <!-- aidoc:v1 sig=62502e3 body=f2a846f -->
    [Test]
    public async Task ParseWeight_WhenInvalidObservation_ShouldReturnOriginal()
    {
        var obs = new BasePatientObservation(); // No es PatientObservation, por lo que no se puede convertir


        var result = await _calculatedObservations.ParseWeight(obs);

        Assert.That(result, Is.EqualTo(obs));
    }

    /// <summary>
    /// Verifies that when the patient temperature <see cref="PatientObservation"/> and the latest incubator temperature observation are both recent, <c>CalculateTempGradient</c> triggers an <c>InsertObservation</c> call exactly once to persist the computed <c>Temp_Gradient</c> value (incubator minus patient temperature).
    /// </summary>
    /// <!-- aidoc:v1 sig=dadceb5 body=9a088dd -->
    [Test]
    public async Task CalculateTempGradient_WhenTempPatientAndTempIncubatorAreRecent_ShouldCalculateGradient()
    {
        var now = DateTime.UtcNow;
        var patientId = ObjectId.GenerateNewId();
        var tempPatientObs = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Name = "Temp_Patient",
            Time = now,
            Value = 36.5
        };
        var tempIncubatorObs = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Name = "Temp_Incubator",
            Time = now.AddMinutes(-10), // 10 minutos antes
            Value = 37.0
        };

        var tempGradientObs = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Name = "Temp_Gradient",
            Time = now.AddSeconds(1),
            Value = 37.0
        };
        _observationServiceMock.Setup(s => s.FindAnyWithSameDate(patientId, now, "Temp_Gradient"))
            .ReturnsAsync([tempGradientObs]);

        _observationServiceMock.Setup(s => s.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([tempIncubatorObs]);

        _observationServiceMock.Setup(s => s.InsertObservation(
            It.IsAny<PatientObservation>(),
            It.IsAny<bool>(),
            It.IsAny<bool>()
        )).Callback<PatientObservation, bool, bool>((obs, _, _) =>
        {
            Action assertions = () =>
            {
                Assert.That(obs.Name, Is.EqualTo("Temp_Gradient"));
                Assert.That(Math.Abs((double)obs.Value - (37.0 - 36.5)), Is.LessThan(0.001));
            };
        });


        await _calculatedObservations.CalculateTempGradient(tempPatientObs);


        _observationServiceMock.Verify(s => s.InsertObservation(
            It.IsAny<PatientObservation>(),
            It.IsAny<bool>(),
            It.IsAny<bool>()
        ), Times.Once());
    }

    /// <summary>
    /// Verifies that the temperature gradient calculation does not persist a new <see cref="PatientObservation"/>
    /// when the lookup for the complementary temperature reading returns no observations.
    /// </summary>
    /// <!-- aidoc:v1 sig=eb711fb body=d83838d -->
    [Test]
    public async Task CalculateTempGradient_WhenOneTemperatureIsMissing_ShouldNotCalculateGradient()
    {
        var patientId = ObjectId.GenerateNewId();
        var tempPatientObs = new PatientObservation
        {
            PatientId = patientId,
            Name = "Temp_Patient",
            Time = DateTime.UtcNow,
            Value = 36.5
        };

        // Configuramos el mock para que no devuelva ninguna observación para Temp_Incubator
        _observationServiceMock.Setup(s => s.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);


        await _calculatedObservations.CalculateTempGradient(tempPatientObs);


        _observationServiceMock.Verify(s => s.InsertObservation(
            It.IsAny<PatientObservation>(),
            It.IsAny<bool>(),
            It.IsAny<bool>()
        ), Times.Never()); // Verificamos que InsertObservation no se llama
    }

    /// <summary>
    /// Verifies that the intravenous line observation calculation maps <see cref="PatientObservation.Name"/> to "IntravenousLines", preserves <see cref="PatientObservation.PatientId"/>, and ensures <see cref="PatientObservation.Time"/> is not earlier than the current time when no prior intravenous lines observation exists.
    /// </summary>
    /// <!-- aidoc:v1 sig=6d30754 body=9402c27 -->
    [Test]
    public async Task CalculateIntravenousLineObservation_ShouldCalculateObservationAndAdjustTimeIfNecessary()
    {
        var patientId = ObjectId.GenerateNewId();
        var currentTime = DateTime.UtcNow;
        var obs = new PatientObservation
        {
            PatientId = patientId,
            Name = "IntravenousLine",
            Value = new PatientIntravenousLinesValue(),
            Time = currentTime
        };

        _observationServiceMock.Setup(s => s.FindLastIntravenousLinesObservationByLocation(patientId))
            .ReturnsAsync([]);

        PatientObservation? insertedObservation = null;
        _observationServiceMock.Setup(s =>
                s.InsertObservation(It.IsAny<PatientObservation>(), It.IsAny<bool>(), It.IsAny<bool>()))
            .Callback<PatientObservation, bool, bool>((ob, _, _) => insertedObservation = ob)
            .Returns(Task.CompletedTask);

        _observationServiceMock.Setup(s => s.FindLastObservations(It.IsAny<ObjectId>(), 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        await _calculatedObservations.CalculateIntravenousLineObservation(obs);

        Assert.That(insertedObservation, Is.Not.Null);
        Action assertions = () =>
        {
            Assert.That(insertedObservation!.PatientId, Is.EqualTo(patientId));
            Assert.That(insertedObservation.Name, Is.EqualTo("IntravenousLines"));
            Assert.That(insertedObservation.Time,
                Is.GreaterThanOrEqualTo(currentTime)); // Verificar que la hora no sea anterior a la hora actual
        };
    }

    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.CalculateMonitor(PatientObservation)"/> correctly calculates and inserts a "Monitor" <see cref="PatientObservation"/> when the patient has a valid existing observation matching the configured regional brain saturation code or an active treatment.
    /// </summary>
    /// <!-- aidoc:v1 sig=489567e body=5acaf14 -->
    [Test]
    public async Task CalculateMonitor_WithValidObservationOrTreatment_ShouldCalculateAndInsertObservation()
    {
        var patientId = ObjectId.GenerateNewId();
        var monitorObservation = new PatientObservation
        {
            PatientId = patientId
        };

        var activeObservation = new PatientObservation
        {
            Code = _optionsApiSettings.Value.RegionalBrainSaturation?.FirstOrDefault(),
            PatientId = patientId
        };

        var activeTreatment = new PatientTreatment
        {
            PatientId = patientId
        };


        _observationServiceMock.Setup(s =>
                s.FindLastObservations(It.IsAny<ObjectId>(), It.IsAny<int>(), It.IsAny<List<string>>()))
            .ReturnsAsync([activeObservation]);

        _treatmentServiceMock.Setup(s => s.GetActiveTreatmentsByPatient(It.IsAny<ObjectId>()))
            .ReturnsAsync(new List<PatientTreatment> { activeTreatment });

        _observationServiceMock.Setup(s => s.InsertObservation(It.IsAny<PatientObservation>(), true, true))
            .Returns(Task.CompletedTask)
            .Verifiable();


        await _calculatedObservations.CalculateMonitor(monitorObservation);


        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
                o.PatientId == patientId &&
                o.Name == "Monitor" &&
                o.CodingSystem == "ADAS" &&
                o.Min != null && Math.Abs(o.Min.Value - 0) < 0.01 &&
                o.Max != null && Math.Abs(o.Max.Value - 3) < 0.01
            ), It.IsAny<bool>(), It.IsAny<bool>()),
            Times.Once());
    }

    /// <summary>
    /// Verifies that <c>CalculateMonitor</c> calculates and inserts a new Monitor observation for the patient when invoked with a <see cref="PatientTreatment"/>, provided an active treatment exists and a matching non-expired <see cref="PatientObservation"/> is returned by <c>FindLastObservations</c>.
    /// </summary>
    /// <!-- aidoc:v1 sig=4a87817 body=2f68585 -->
    [Test]
    public async Task CalculateMonitor_WithPatientTreatment_ShouldCalculateAndInsertObservation()
    {
        // Arrange
        var patientId = ObjectId.GenerateNewId();
        var monitorTreatment = new PatientTreatment
        {
            PatientId = patientId
        };

        var activeTreatment = new PatientTreatment
        {
            PatientId = patientId
        };

        var patientObservation = new PatientObservation
        {
            Code = _optionsApiSettings.Value.Transcutaneous?.First(),
            PatientId = patientId,
            Expired = false
        };

        // Simular respuestas de los servicios
        _treatmentServiceMock.Setup(s => s.GetActiveTreatmentsByPatient(It.IsAny<ObjectId>()))
            .ReturnsAsync(new List<PatientTreatment> { activeTreatment });

        _observationServiceMock.Setup(s => s.InsertObservation(It.IsAny<PatientObservation>(), true, true))
            .Returns(Task.CompletedTask)
            .Verifiable();
        _observationServiceMock.Setup(s => s.FindLastObservations(patientId, 1, It.IsAny<List<string>>()))
            .ReturnsAsync([patientObservation]);
        // Act
        await _calculatedObservations.CalculateMonitor(monitorTreatment);

        // Assert
        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
                o.PatientId == patientId &&
                o.Name == "Monitor" &&
                o.CodingSystem == "ADAS" &&
                o.Min != null && Math.Abs(o.Min.Value - 0) < 0.01 &&
                o.Max != null && Math.Abs(o.Max.Value - 3) < 0.01
            ), It.IsAny<bool>(), It.IsAny<bool>()),
            Times.Once());
    }

    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.CalculateMonitor(PatientObservation)"/> does not invoke
    /// <see cref="ObservationService.InsertObservation(PatientObservation, bool, bool)"/> when the supplied
    /// <see cref="PatientObservation"/> contains incomplete data (only <see cref="BasePatientObservation.PatientId"/>
    /// is populated), and the prior observations returned by <see cref="ObservationService.FindLastObservations"/> are empty.
    /// </summary>
    /// <!-- aidoc:v1 sig=62f5906 body=d3d0023 -->
    [Test]
    public async Task CalculateMonitor_WithIncompleteData_ShouldNotInsertObservation()
    {
        // Arrange
        var patientId = ObjectId.GenerateNewId();
        var incompleteObservation = new PatientObservation
        {
            PatientId = patientId
            // Proporcionar datos incompletos o irrelevantes
        };

        // Simular respuestas de los servicios
        _observationServiceMock.Setup(s =>
                s.FindLastObservations(It.IsAny<ObjectId>(), It.IsAny<int>(), It.IsAny<List<string>>()))
            .ReturnsAsync([]);

        _observationServiceMock.Setup(s => s.InsertObservation(It.IsAny<PatientObservation>(), true, true))
            .Returns(Task.CompletedTask)
            .Verifiable();

        // Act
        await _calculatedObservations.CalculateMonitor(incompleteObservation);

        // Assert
        _observationServiceMock.Verify(
            s => s.InsertObservation(It.IsAny<PatientObservation>(), It.IsAny<bool>(), It.IsAny<bool>()),
            Times.Never());
    }

    /// <summary>
    /// Verifies that the surgery expiration check does not insert the <see cref="PatientObservation"/> when its <see cref="PatientObservation.Expired"/> flag is set to <c>false</c>, ensuring that only expired observations trigger an insertion.
    /// </summary>
    /// <!-- aidoc:v1 sig=51d7692 body=0f0f138 -->
    [Test]
    public async Task CheckSurgeryExpired_WhenNotExpired_DoesNotInsertObservation()
    {
        var obs = new PatientObservation
        {
            Expired = false
        };

        await _calculatedObservations.CheckSurgeryExpired(obs);

        _observationServiceMock.Verify(s => s.InsertObservation(It.IsAny<PatientObservation>(), true, false),
            Times.Never);
    }

    /// <summary>
    /// Tests that when a <see cref="PatientObservation"/> has expired, <see cref="CalculatedObservations.CheckSurgeryExpired(PatientObservation)"/> inserts a new <see cref="PatientObservation"/> named "Surgery" with value 0, range 0 to 5, coding system "ADAS", timestamp offset by one second from the original observation, and matching patient identifier and expiry duration.
    /// </summary>
    /// <!-- aidoc:v1 sig=ce416cc body=331e208 -->
    [Test]
    public async Task CheckSurgeryExpired_WhenExpired_InsertsCorrectObservation()
    {
        var initialTime = DateTime.Now;
        var obs = new PatientObservation
        {
            Expired = true,
            PatientId = ObjectId.GenerateNewId(),
            Time = initialTime,
            Expires = 30
        };

        await _calculatedObservations.CheckSurgeryExpired(obs);

        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
            o.PatientId == obs.PatientId &&
            o.Name == "Surgery" &&
            o.Min != null && Math.Abs(o.Min.Value - 0) < 0.01 &&
            o.Max != null && Math.Abs(o.Max.Value - 5) < 0.01 &&
            o.CodingSystem == "ADAS" &&
            o.Time == initialTime.AddSeconds(1) &&
            o.Value.Equals(0) && // Asegúrate de que la comparación de 'o.Value' sea apropiada para su tipo
            o.Expires == 30
        ), true, false), Times.Once);
    }

    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.CalculateComplexity"/> inserts a new complexity observation when processing a patient observation in a non-ECMO treatment context, ensuring the active treatments and recent observations are retrieved and the resulting complexity value is persisted.
    /// </summary>
    /// <!-- aidoc:v1 sig=83462d4 body=c26dd24 -->
    [Test]
    public async Task CalculateComplexity_NewObservation_NoECMO_AddsComplexity()
    {
        var patientId = ObjectId.GenerateNewId();
        var patientTreatment = new PatientTreatment
        {
            Id = patientId
        };

        var patientObservation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Name = "Weight_Current",
            Value = 10
        };

        var complelxity = new PatientObservation
        {
            Id = patientId,
            Value = 1
        };

        // Mock de datos de tratamiento activo
        var activeTreatments = new List<PatientTreatment> { patientTreatment };
        _treatmentServiceMock.Setup(m => m.GetActiveTreatmentsByPatient(It.IsAny<ObjectId>()))
            .ReturnsAsync(activeTreatments);

        // Mock de datos de observación
        var observations = new List<PatientObservation> { patientObservation };
        _observationServiceMock.Setup(m => m.FindLastObservations(It.IsAny<ObjectId>(), 1, It.IsAny<List<string>>()))
            .ReturnsAsync(observations);

        var complexityObservations = new List<PatientObservation> { complelxity };
        _observationServiceMock.Setup(m => m.FindLastObservations(It.IsAny<ObjectId>(), 1, It.IsAny<List<string>>()))
            .ReturnsAsync(complexityObservations);

        var obs = patientObservation as BasePatientObservation;
        var result = await _calculatedObservations.CalculateComplexity(obs);


        // Verifica que el valor de complejidad calculado sea el esperado
        Assert.That(result.Name, Is.EqualTo("Weight_Current"));

        // Verifica que se hayan llamado los métodos esperados en los servicios mockeados
        _treatmentServiceMock.Verify(m => m.GetActiveTreatmentsByPatient(It.IsAny<ObjectId>()), Times.Once);

        _observationServiceMock.Verify(m => m.FindLastObservations(It.IsAny<ObjectId>(), 1, It.IsAny<List<string>>()),
            Times.Exactly(3));


        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
            o.PatientId == obs.PatientId &&
            o.Name == "Complexity" &&
            o.CodingSystem == "ADAS" &&
            Equals(o.Value, 7)
        ), true, false), Times.Once);
    }

    /// <summary>
    /// Verifies that when an expired <see cref="PatientObservation"/> is passed to the complexity calculation,
    /// no new complexity record is inserted into the database, ensuring that expired observations are excluded
    /// from contributing to the patient's calculated complexity value.
    /// </summary>
    /// <!-- aidoc:v1 sig=dbd49ea body=f99d711 -->
    [Test]
    public async Task CalculateComplexity_ExpiredObservation_DoesNotAddToComplexity()
    {
        // Configuración inicial
        var patientId = ObjectId.GenerateNewId();
        var expiredPatientObservation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Name = "Weight_Current",
            Value = 10,
            Expired = true // Observación expirada
        };

        var observations = new List<PatientObservation> { expiredPatientObservation };

        _observationServiceMock.Setup(m => m.FindLastObservations(It.IsAny<ObjectId>(), 1, It.IsAny<List<string>>()))
            .ReturnsAsync(observations);

        var obs = expiredPatientObservation as BasePatientObservation;
        var result = await _calculatedObservations.CalculateComplexity(obs);

        // Verificaciones
        Assert.That(result.Name, Is.EqualTo("Weight_Current"));

        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
                o.PatientId == obs.PatientId &&
                o.Name == "Complexity" &&
                Equals(o.Value, 0) // Valor de complejidad no debe cambiar
        ), true, true), Times.Never); // No se debe llamar InsertObservation
    }

    /// <summary>
    /// Verifies that when an active treatment includes ECMO, <see cref="CalculatedObservations.CalculateComplexity(BasePatientObservation)"/>
    /// preserves the original <see cref="PatientObservation"/> value and records a derived <c>Complexity</c> observation labeled
    /// "1 ECMO" for the patient.
    /// </summary>
    /// <!-- aidoc:v1 sig=188c976 body=8b97b7c -->
    [Test]
    public async Task CalculateComplexity_ECMOActive_AdjustsComplexity()
    {
        var code = new Code { Identifier = "705923009" };

        // Configuración inicial
        var patientId = ObjectId.GenerateNewId();
        var observation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Name = "ECMO",
            Value = 10
        };

        var lastObservation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Name = "Surgery",
            Value = 1
        };

        var patientTreatment = new PatientTreatment
        {
            Id = patientId
        };

        patientTreatment.RequestedGiveCodes.Add(code);

        // Mock de datos de tratamiento activo
        var activeTreatments = new List<PatientTreatment> { patientTreatment };
        _treatmentServiceMock.Setup(m => m.GetActiveTreatmentsByPatient(It.IsAny<ObjectId>()))
            .ReturnsAsync(activeTreatments);

        var observations = new List<PatientObservation> { lastObservation };

        _observationServiceMock.Setup(m => m.FindLastObservations(It.IsAny<ObjectId>(), 1, It.IsAny<List<string>>()))
            .ReturnsAsync(observations);

        BasePatientObservation obs = observation;
        var result = await _calculatedObservations.CalculateComplexity(obs);

        // Verificaciones
        Assert.That(result.Name, Is.EqualTo("ECMO"));

        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
                o.PatientId == obs.PatientId &&
                o.Name == "ECMO" &&
                Equals(o.Value, 10) // Valor de complejidad no debe cambiar
        ), true, true), Times.Once);

        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
            o.PatientId == obs.PatientId &&
            o.Name == "Complexity" &&
            Equals(o.Value, "1 ECMO")
        ), true, false), Times.Once);
    }

    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.CheckObsExistsAndIncrementTime"/> increments the <see cref="BasePatientObservation.Time"/> by one second beyond the existing observation when the lookup returns a <see cref="PatientObservation"/> sharing the same timestamp, patient, and observation name as the supplied instance.
    /// </summary>
    /// <!-- aidoc:v1 sig=4530eaf body=d89050c -->
    [Test]
    public async Task CheckObsExistsAndIncrementTime_SameHourObservation_IncrementsTime()
    {
        // Configuración inicial
        var patientId = ObjectId.GenerateNewId();
        var initialTime = DateTime.UtcNow;
        var sameHourObservation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Time = initialTime,
            Name = "TestObservation"
        };

        var existingObservation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Time = initialTime, // Misma hora que sameHourObservation
            Name = "TestObservation"
        };

        // Mock del servicio de observación para que retorne una observación existente en la misma hora
        _observationServiceMock.Setup(m =>
                m.FindLastBeforeDate(It.IsAny<ObjectId>(), It.IsAny<DateTime>(), It.IsAny<string>()))
            .ReturnsAsync(existingObservation);

        var obs = sameHourObservation as BasePatientObservation;
        var result = await _calculatedObservations.CheckObsExistsAndIncrementTime(obs);

        // Verificaciones
        var resultObs = result as PatientObservation;
        Assert.That(resultObs, Is.Not.Null);
        Assert.That(resultObs!.Time, Is.GreaterThan(initialTime)); // Verifica que el tiempo ha sido incrementado
        Assert.That(resultObs.Time,
            Is.EqualTo(existingObservation.Time.AddSeconds(1))); // Verifica que el tiempo se incrementó en 1 segundo
    }


    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.CheckObsWithSameTimeExistsAndIncrementTime"/> increments the <see cref="BasePatientObservation.Time"/> of the supplied <see cref="PatientObservation"/> by one second and assigns a new <see cref="BasePatientObservation.Id"/> when another observation with the same time and <see cref="BasePatientObservation.Name"/> already exists for the same <see cref="BasePatientObservation.PatientId"/>.
    /// </summary>
    /// <!-- aidoc:v1 sig=3e1e2ae body=5370e25 -->
    [Test]
    public async Task CheckObsWithSameTimeExistsAndIncrementTime_WhenObservationWithSameTimeExists_IncrementsTime()
    {
        // Configuración inicial
        var patientId = ObjectId.GenerateNewId();
        var observationTime = DateTime.UtcNow;
        const string observationName = "TestObservation";

        var newObservation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Time = observationTime,
            Name = observationName
        };

        var existingObservation = new PatientObservation
        {
            Id = ObjectId.GenerateNewId(),
            PatientId = patientId,
            Time = observationTime, // Misma hora y nombre que newObservation
            Name = observationName
        };

        // Mock del servicio de observación para que retorne una observación existente con el mismo tiempo y nombre
        _observationServiceMock.Setup(m => m.FindAnyWithSameDate(patientId, observationTime, observationName))
            .ReturnsAsync([existingObservation]);

        BasePatientObservation obs = newObservation;
        var result = await _calculatedObservations.CheckObsWithSameTimeExistsAndIncrementTime(obs);

        // Verificaciones
        var resultObs = result as PatientObservation;
        Assert.That(resultObs, Is.Not.Null);
        using (Assert.EnterMultipleScope())
        {
            {
                Assert.That(resultObs!.Time,
                    Is.EqualTo(observationTime.AddSeconds(1))); // Verifica que el tiempo se haya incrementado en 1 segundo
                Assert.That(existingObservation.Id,
                    Is.Not.EqualTo(resultObs.Id)); // Verifica que el Id sea diferente al de la observación existente
            }
            ;
        }
    }

    /// <summary>
    /// Verifies that <see cref="CalculatedObservations.CheckTreatmentMedicines"/> correctly processes a treatment whose notes contain a parental nutrition formulation (comment "NPT" with comment type "formularybaseformulation"), looking up the associated <see cref="Medicine"/> by code, retrieving active treatments and the last medication observation for the patient, and inserting a new <see cref="PatientObservation"/> with <see cref="BasePatientObservation.Name"/> "Medication", <see cref="BasePatientObservation.CodingSystem"/> "ADAS" and <see cref="BasePatientObservation.Value"/> 1.
    /// </summary>
    /// <!-- aidoc:v1 sig=28e758c body=0996b61 -->
    [Test]
    public async Task CheckTreatmentMedicines_ProcessesTreatmentCorrectly_WithParentalNutritionMedicine()
    {
        var patientId = ObjectId.GenerateNewId();
        var code = new Code { Identifier = "705923009" };

        var medicationObs = new PatientObservation { PatientId = patientId, Value = 2 };

        // Configuración inicial
        var treatment = new PatientTreatment
        {
            PatientId = patientId,
            Notes =
            [
                new Note { Comment = "NPT", CommentType = "formularybaseformulation" }
            ],
            RequestedGiveCodes = [code],
            RequestedGiveTreatment = "Medicación"
        };

        var medicine = new Medicine { Codes = [code.Identifier] };

        var lastMedicationObs = new List<PatientObservation> { medicationObs };

        var expectedMedicines = new List<Medicine> { medicine };

        var activeTreatments = new List<PatientTreatment> { treatment };

        // Mock de medicineService para que devuelva medicinas esperadas          

        _medicineServiceMock.Setup(m => m.GetByCodeOrNote(It.IsAny<List<string>>()))
            .ReturnsAsync(expectedMedicines);

        _medicineServiceMock.Setup(m => m.GetMedicinesOfTreatments(It.IsAny<List<PatientTreatment>>()))
            .ReturnsAsync(expectedMedicines);

        _treatmentServiceMock.Setup(m => m.GetActiveTreatmentsByPatient(It.IsAny<ObjectId>()))
            .ReturnsAsync(activeTreatments);

        _observationServiceMock
            .Setup(m => m.FindLastObservations(It.IsAny<ObjectId>(), 1, new List<string> { "Medication" }))
            .ReturnsAsync(lastMedicationObs);

        _observationServiceMock.Setup(s => s.FindLastObservations(It.IsAny<ObjectId>(), 1, It.IsAny<List<string>>()))
            .ReturnsAsync([]);
        // Otras configuraciones de mock según sea necesario

        // Llamada al método bajo prueba
        await _calculatedObservations.CheckTreatmentMedicines(treatment);

        // Verificaciones
        // Verifica que las llamadas a los servicios mockeados son como se esperan
        // Verifica que la lógica de procesamiento de medicamentos es correcta
        // Puedes usar Assert o Verify de Moq según corresponda
        // ...

        _observationServiceMock.Verify(s => s.InsertObservation(It.Is<PatientObservation>(o =>
            o.PatientId == patientId &&
            o.Name == "Medication" &&
            o.CodingSystem == "ADAS" &&
            Equals(o.Value, 1)
        ), true, false), Times.Once);
    }
}